Possible Interaction: Octreotide and Secretin

“ Octreotide (Sandostatin 201-995) has aninhibitory effect on gastric, intestinal, and pancreaticsecretions and hepatic and splachnic blood flow.”

“The pancreatic secretory volume decreased markedly after the first injection of octreotide and remained low for the duration of the treatment period.”

“ Octreotide inhibits gastroenteropancreatic secretion , especially of insulin, glucagon, pancreatic polypeptide, gastric inhibitory polypeptide, and gastrin.”

“Like somatostatin, octreotide inhibits the release of growth hormone, insulin, glucagon, gastrin, gastric inhibitory peptide, pancreatic polypeptide, secretin , neurotensin, and motilin.”

“ Octreotide also reduced synergistic amylase secretion by secretin or VIP in combination with calcium ionophore A23187.”

“On the other hand, octreotide inhibited synergistic amylase secretion induced by secretin or VIP in combination with cholecystokinin (CCK).”

“Intravenous infusions of octreotide or somatostatin (1 nmol kg−1 h−1) inhibited periodic pancreatic secretion and the potentiation of fluid and bicarbonate responses to secretin at 60 ng kg−1 h−1 associated with the interdigestive gastroduodenal motility peaks (migrating motor complex).”

“It is concluded that both octreotide and somatostatin, like atropine, inhibit interdigestive pancreatic secretion and the responses to small, but not large, doses of secretin and CCK-8 in conscious dogs.”

“Pancreatic protein and enzyme responses to secretin and CCK-8 at 50 and 100, but not at 200 and 400, ng kg−1 h- ' were inhibited by octreotide and somatostatin.”