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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Octreotide
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In the short-term, octreotide significantly decreased the levels of serum GH, IGF-I, calcium , osteocalcin, carboxyterminal propeptide of type I collagen and alkaline phosphatase plus urinary excretion of calcium.”
Long-term effects of octreotide on markers of bone metabolism in acromegaly: Evidence of increased serum parathormone concentrations“ Calcium appears to inhibit octreotide suppression of glucagon and insulin secretion in patients with glucagonoma and insulinoma, respectively.”
“ Octreotide enhanced calcium retention by 30% (96 mg daily [P < 0.04]) in 7 boys for whom complete data (diet, urine, and fecal calcium) were available.”
“Somatostatin and octreotide (100 nM) promptly and reversibly counteracted glucose stimulated elevations of the concentration of cytoplasmic Ca2+ ([Ca2+]i) in mouse pancreatic beta-cells.”
“In rat pituitary tumour cells (GC cells), spontaneous oscillations of the intracellular concentration of Ca2+ ([Ca2+]i) induce growth hormone (GH) secretion that is inhibited by octreotide , a somatostatin (SRIF) agonist which binds to SRIF subtype (sst) receptor 2.”
Somatostatin‐induced control of cytosolic free calcium in pituitary tumour cells
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