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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Octreotide
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Centrally acting agents, which suppress ACTH secretion, include cabergoline, octreotide , as well as the investigational agents pasireotide, bexarotene, and lapatinib, which are being studied in patients with pituitary tumors.”
Advances in medical therapies for Cushing's syndrome.“Somatostatin analogs octreotide and pasireotide (SOM230) significantly suppressed CRH-induced ACTH and cAMP production in AtT20 cells and reduced ERK and p38 phosphorylation.”
“Ten nmol/l OCT slightly inhibited ACTH release in only one of five cultures (- 28%).”
“ Octreotide remains less potent than pasireotide and cabergoline with respect to in vitro inhibition of ACTH secretion.”
“While taking octreotide, corticotropin values decreased, accompanied by depigmentation and development of signs of adrenal insufficiency, which led to the reinstitution of supplemental hydrocortisone.”
“In pathological conditions of a low endogenous cortisol level, i.e. in patients with adrenal insufficiency and in patients with Nelson’s syndrome, SS and sst2-preferring SS analogs (SSA), such as octreotide , are able to lower circulating ACTH and cortisol levels.”
“Administration of octreotide-LAR reduced ACTH levels from 230,000 to 30,000 pg/ml in patient 1, and controlled symptoms of carcinoid syndrome and neoplasic lesions in patient 2; treatment with subcutaneous octreotide in patient 3 controlled carcinoid syndrome and partially reduced symptoms of hypercortisolism.”
“A paradoxical rise of ACTH from 384 to 717 pg/mL was observed after subcutaneous administration of 500 micrograms octreotide.”
“ Octreotide therapy can produce a rapid and sustained reduction of ACTH and cortisol levels in patients with ectopic ACTH-dependent Cushing's syndrome and, in some, may be the only long-term therapy possible.”
“CRH-stimulated ACTH secretion was suppressed by octreotide.”
“In conclusion, we showed that octreotide in most cases could inhibit the ACTH release from human corticotropic adenoma cells in vitro but had no suppressive effect on ACTH levels of patients with Cushing's disease in vivo.”
“In four of six cell cultures, octreotide (1 nmol/l-1 mumol/l) inhibited basal ACTH secretion in a dose-dependent manner.”
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