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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Noscapine and Serum Albumin, Human

Research Papers that Mention the Interaction

Molecular site marker, molecular docking, and MD simulation results indicated that the principal binding site of HSA for NOS is site I. Synchronous fluorescence spectra, FTIR, 3D fluorescence, CD spectra, and MD simulation results reveal that NOS induced the structural change in HSA.
The corresponding thermodynamic result shows that binding of NOS with HSA is exothermic in nature, involving electrostatic interactions as major binding forces.
The steady-state fluorescence results showed that fluorescence intensity of HSA decreased in the presence of NOS via a static quenching mechanism, which involves ground state complex formation between NOS and HSA.
Molecular pharmaceutics  •  2019  |  View Paper