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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nortriptyline
supplement:
Yohimbine
Research Papers that Mention the Interaction
“ Yohimbine potentiated the effect of nortriptyline or amitriptyline administered in a single dose and the effect of imipramine and amitriptyline given for 2 weeks.”
Presynaptic α-adrenoceptors and the action of tricyclic antidepressant drugs in behavioural despair in rats“However, the beneficial effects of NT on sustained attention and premature responses were attenuated by pretreatment with either yohimbine or propranolol.”
α2- and β-adrenoceptors involvement in nortriptyline modulation of auditory sustained attention and impulsivity“The reduction of noradrenaline (NA) utilization in the brain evoked by a single dose of antidepressants and the increase of NA utilization induced by chronic treatment with imipramine or nortriptyline were prevented by yohimbine.”
“ Yohimbine and phentolamine administered in doses regarded as blocking presynaptic alpha-adrenoreceptors counteracted locomotor sedation elicited in rats by antidepressant drugs (imipramine, nortriptyline and amitriptyline).”
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