Possible Interaction: Norfloxacin and Vitamin E

“Expression of BcnA was required for the adjuvant effect of vitamin E. These results were replicated in vivo using the Galleria mellonella larva infection model whereby vitamin E treatment, in combination with norfloxacin , significantly increased larva survival upon infection in a BcnA-dependent manner.”

“In this study, we investigated water-soluble and liposoluble forms of … antibiotic binding by BcnA. Our results demonstrate that in vitro, both vitamin E forms bind strongly to … the MICs of norfloxacin (a fluoroquinolone) and ceftazidime (a β-lactam), both of … molecules representing two different chemical classes of antibiotics.”