Possible Interaction: Norepinephrine and Yohimbine

“In addition, these results indicate that ethanol and yohimbine may act additively to increase ethanol intoxication and that they may increase NE turnover through different physiological mechanisms.”

“ Yohimbine significantly raised systolic blood pressure (F = 3.07, P < 0.03), plasma NE levels (F = 12.11, P < 0.00) and cortisol levels (F = 4.82, P < 0.02), but had no effect on epinephrine levels.”

“ Yohimbine , an alpha 2 adrenoreceptor antagonist, enhances norepinephrine (NE) release and increases sympathetic activity.”

“ Noradrenaline also slightly shortened QS2c (Δmax –22 ms), and this was potentiated by both doxazosin and yohimbine and completely blocked by bisoprolol.”

“ noradrenaline increased Pdiast (Δmax 17 mmHg) and this was nearly completely suppressed by doxazosin but only slightly blunted by yohimbine.”

“There is a significant correlation between plasma norepinephrine levels and yohimbine AUC or Cmax.”

“ Yohimbine (10 mg) increased both salivary outflow and plasma noradrenaline levels for 4 h. Pharmacokinetic parameters (t1/2, tmax, Cmax and AUCexp) and plasma concentrations of noradrenaline were higher in patients treated with tricyclic antidepressants than in controls.”

“In the supine position, yohimbine increased plasma noradrenaline and NEFA concentrations by about 100% and 55% respectively.”

“Standing after yohimbine administration promoted large increases in plasma noradrenaline and NEFA concentrations.”

“In agreement with previous studies, we found that yohimbine causes dose-dependent increases in blood pressure, heart rate, and plasma NE.”

“We conclude that yohimbine increases plasma NE levels by increasing the rate of NE release from sympathetic nerves, and probably increases epinephrine release from the adrenals.”

“CSF NE was significantly higher following yohimbine as compared to placebo.”

“Plasma norepinephrine concentrations were increased (40-50%) after oral yohimbine administration.”

“A dose of yohimbine was used which raised plasma norepinephrine from 379 +/- 74 (S.E.) to 730 +/- 143 pg/ml and mean arterial pressure from 83 +/- 4 to 92 +/- 5 torr (p less than 0.025).”