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Last Updated: 2 years ago

Possible Interaction: Norepinephrine and Yohimbine

supplement:

Yohimbine

Research Papers that Mention the Interaction

In addition, these results indicate that ethanol and yohimbine may act additively to increase ethanol intoxication and that they may increase NE turnover through different physiological mechanisms.
Psychopharmacology  •  2005  |  View Paper
Yohimbine significantly raised systolic blood pressure (F = 3.07, P < 0.03), plasma NE levels (F = 12.11, P < 0.00) and cortisol levels (F = 4.82, P < 0.02), but had no effect on epinephrine levels.
Yohimbine , an alpha 2 adrenoreceptor antagonist, enhances norepinephrine (NE) release and increases sympathetic activity.
Psychiatry Research  •  1997  |  View Paper
Noradrenaline also slightly shortened QS2c (Δmax –22 ms), and this was potentiated by both doxazosin and yohimbine and completely blocked by bisoprolol.
noradrenaline increased Pdiast (Δmax 17 mmHg) and this was nearly completely suppressed by doxazosin but only slightly blunted by yohimbine.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  1997  |  View Paper
There is a significant correlation between plasma norepinephrine levels and yohimbine AUC or Cmax.
Journal of cardiovascular pharmacology  •  1997  |  View Paper
Yohimbine (10 mg) increased both salivary outflow and plasma noradrenaline levels for 4 h. Pharmacokinetic parameters (t1/2, tmax, Cmax and AUCexp) and plasma concentrations of noradrenaline were higher in patients treated with tricyclic antidepressants than in controls.
British journal of clinical pharmacology  •  1994  |  View Paper
In the supine position, yohimbine increased plasma noradrenaline and NEFA concentrations by about 100% and 55% respectively.
Standing after yohimbine administration promoted large increases in plasma noradrenaline and NEFA concentrations.
British journal of clinical pharmacology  •  1993  |  View Paper
In agreement with previous studies, we found that yohimbine causes dose-dependent increases in blood pressure, heart rate, and plasma NE.
We conclude that yohimbine increases plasma NE levels by increasing the rate of NE release from sympathetic nerves, and probably increases epinephrine release from the adrenals.
The Journal of clinical endocrinology and metabolism  •  1991  |  View Paper
CSF NE was significantly higher following yohimbine as compared to placebo.
Neuroendocrinology  •  1989  |  View Paper
Plasma norepinephrine concentrations were increased (40-50%) after oral yohimbine administration.
European journal of clinical investigation  •  1988  |  View Paper
A dose of yohimbine was used which raised plasma norepinephrine from 379 +/- 74 (S.E.) to 730 +/- 143 pg/ml and mean arterial pressure from 83 +/- 4 to 92 +/- 5 torr (p less than 0.025).
Life sciences  •  1986  |  View Paper
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