Possible Interaction: Norepinephrine and Tyrosine

“Following pretreatment with idazoxan, tyrosine stimulated the secretion of ACTH and noradrenaline in a dose‐dependent manner, although neither tyrosine nor idazoxan on their own had any effect on the secretion of either substance.”

“ NE increased tyrosine phosphorylation of Pyk2, and this response was neither blocked by BAPTA nor mimicked by TG.”

“Other substances found to inhibit the iodination of tyrosine by the thyroid particulate fraction are DPNH, TPNH, cysteine, epinephrine, norepinephrine , serotonin, ergothioneine, thiohistidine and dichlorophenol.”

“ L-Tyrosine and L-Dopa significantly (P < 0.01) increased intracellular NE.”

“ L-tyrosine plus ACh (60 microM) or (120 microM) significantly increased (P < 0.01) intracellular L-Dopa and NE versus control, versus L-tyrosine alone and versus ACh alone.”

“ L-tyrosine significantly increased (P < 0.01) L-Dopa and norepinephrine (NE) content of lymphocytes.”

“ Noradrenaline stimulated tyrosine phosphorylation of the p85 subunit of PI 3-kinase, and a phosphorylated tyrosine protein could be co-immunoprecipitated with anti-p85 of PI 3-kinase.”

“Third, the administration of tyrosine may minimize or reverse stress-induced performance decrement by increasing depleted brain norepinephrine levels.”

“The amino acid L-tyrosine , a catecholamine precursor, is capable of augmenting central dopamine norepinephrine.”

“ Tyrosine ingestion induced within 45 min a significant but short-lasting (approximately 30 min) increase in plasma concentrations of NE , EPI, and DA and a coincident decrease in plasma DOPAC levels.”

“A single … dose of tyrosine (100 or 150 mg/kg) caused … increases in urinary levels of norepinephrine (NE), epinephrine (E), dopamine (DA), 3-methoxy-4-hydroxyphenylglycol (MHPG), vanilmandelic acid (VMA), and homovanillic acid (HVA) during the first 2 hr after its ingestion; water administration failed to produce such changes.”