Possible Interaction: Norepinephrine and Taurine

“Furthermore, the decreased levels of 5-hydroxytryptamine, dopamine, noradrenaline ; the increased levels of glutamate, corticosterone; and the decreased expressions of fibroblast growth factor-2, vascular endothelial growth factor and brain derived neurotrophic factor in depressive rats were hindered by taurine pre-administration.”

“These effects of NE on cardiomyocytes were diminished by taurine (0.5 mg/kg) but not beta-alanine.”

“ Taurine added to the perfusate suppressed norepinephrine (NE) overflow and the pressor response mediated by electrical stimulation of isolated perfused mesenteric arteries.”

“ Taurine showed a greater suppressive effect on NE overflow and the pressor response mediated by electrical stimulation in SHR/Izm rats than in WKY/Izm rats.”

“ Exogenous noradrenaline (9 min) caused a concentration-dependent overflow of taurine with a maximal effect at 162 μmol/1, amounting to 33% of the electrically-evoked overflow.”

“Systemic parenteral administration of taurine caused no significant changes in brain monoamines, body temperature or behaviour but decreased the heart noradrenaline levels.”

“TAU content was differentially modified by acute vs. chronic surgeries, thus indicating the possible existence of hypothalamic interactions between TAU and NE to regulate pituitary hormone secretion.”

“We recently showed that chronic taurine supplementation is associated with attenuation of contractile responses of rat aorta to norepinephrine and potassium chloride.”

“ Norepinephrine increased the osmosensitive taurine efflux at about the same extent as dbcAMP and forskolin, and this was reduced by PKA blockers.”

“The above results suggest that taurine in AHA attenuates blood pressure by increasing the content of norepinephrine , probably mediated by beta-adrenergic receptor.”

“Vasocontraction induced by norepinephrine (NE) was significantly decreased by taurine.”