Possible Interaction: Norepinephrine and Quinine

“The specific noradrenaline NA ) uptake inhibitors, desipramine and viloxazine, but not maprotiline, were also found to reduce the immobility time when pretreated with quinine.”

“… quinine and quinidine also inhibited … of [3H]5-HT, [3H]noradrenaline and [3H]dopamine into rat brain synaptosomes with IC50 values in the range 0.13-12.4 microM. The … each drug to inhibit [3H]5-HT uptake was significantly higher than that for [3H]noradrenaline or [3H]dopamine.”

“ Quinine (1 mM) and the bee venom neurotoxin apamin (10 nM) greatly reduced the effect of ATP, noradrenaline and A23187 on K content without affecting the changes in 45Ca movement.”

“The blocking effect of the quinine diet on NE feeding is consistent with other evidence which suggests that NE mediated the eating behavior induced by glucoprivation.”

“The quinine diet completely blocked the NE feeding response, while the fat diet produced a small and unreliable reduction in the feeding response.”

“In isolated rabbit thoracic aortic strips, quinine produced a parallel, dose-related shift of the concentration-response curve for NA to the right but did not affect the maximum responses.”

“ Quinine caused a marked reduction in the noradrenaline (NA) pressor response, blockade of the adrenaline (A) pressor response, partial blunting of the angiotensin II (AII) pressor effect but no change in the depressor effect of isoprenaline (I).”