Possible Interaction: Norepinephrine and Procaine

“ Procaine also inhibited uptake of norepinephrine (NE) and serotonin (5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells.”

“ Procaine and lignocaine in local anaesthetic concentrations abolished the responses to transmural stimulation but potentiated the contractions produced by added noradrenaline.”

“3 Noradrenaline , in the presence of 10 mm procaine , increased 45Ca‐influx and 45Ca‐content.”

“Furthermore, the simultaneous increase in 45Ca influx and inhibition of inositol‐1,4,5‐trisphosphate formation in tissues treated with procaine plus noradrenaline indicates that Ca2+ influx is independent of inositol‐1,4,5‐trisphosphate formation.”

“ Procaine blocked the noradrenaline‐induced 45Ca‐efflux, the increase in total inositol phosphates, the increase in inositol‐1,4,5‐trisphosphate, and contraction.”

“Addition of procaine significantly enhanced SHR contractility to NE with no effect on control strips.”

“ Procaine reversibly reduced the slow IPSP and noradrenaline hyperpolarization without affecting the fast EPSP or slow EPSP at concentrations up to 300 microM.(ABSTRACT TRUNCATED AT 400 WORDS)”

“Two mM procaine inhibited the contractions induced by caffeine, high K+ and norepinephrine.”

“ Procaine (over 2.5 × 10−4m) increased transmitter release from perivascular nerves and blocked the re‐uptake mechanism of released NA.”

“Intraluminal NE in high-K+Ca++-free medium produces a dose-dependent contraction which is selectively antagonized by procaine (1 X 10(-3) M--5 X 10(-3) M).”

“The stimulation by adrenaline and noradrenaline was significantly blocked by the addition of 5 mM procaine.”

“ Procaine induced elevations of serotonin, norepinephrine , and dopamine; norepinephrine elevation occurred in a few brain parts, whereas serotonin and dopamine levels were elevated in all brain regions.”