Possible Interaction: Norepinephrine and Potassium

“An increase in potassium intake may improve the NE hyperreactivity and concomitantly lower BP within the "normotensive" range.”

“In denervated rat mesenteric resistance vessels, a depolarization with potassium (125 mM) before superimposing a norepinephrine tone markedly diminished the effect of pinacidil.”

“These findings indicate that, except for differences due to the normally dilated state of the kidney, the effects of calcium, … potassium on renal vessels are similar to their effects on forelimb and coronary vessels, and that magnesium and probably potassium depress the sensitivity of … forelimb vascular muscle to levarterenol.”

“Hypoxia enhances the ventilatory response to hyperkalaemia, and the stimulatory effects of potassium are further increased when combined with lactic acid or raised concentrations of noradrenaline.”

“Following the decrease of the noradrenaline dose, and administration of potassium , the kalaemia rapidly increased to 5.3 mmol.”

“Erythrocyte sodium and sodium: potassium ratio (Nai:Ki) of hypertensive subjects correlated inversely with their pressor responses to intravenous norepinephrine.”

“ Potassium supplement induced a significant rise in both plasma NE levels and NE outflow rate (p less than 0.01) in the hypertensive patients, while their half-times were significantly shortened (0.89 +/- 0.07 min, p less than 0.01).”

“The pressor responsiveness to exogenously infused NE tended to diminish during the potassium supplement.”

“Baroreceptor sensitivity rose during high potassium intake as demonstrated by the infusion of norepinephrine.”

“the arterial response to noradrenaline was significantly (P less than 0.05) greater than that to potassium.”

“We6,7 have demonstrated that noradrenaline enhances the uptake of both glucose and potassium by lymphocytes, as does insulin in several tissues.”