Possible Interaction: Norepinephrine and Polyphenols

“ TPs administration could effectively reverse the alterations in the concentrations of 5-HT and NE , elevate the activities of SOD and CAT as well as the level of GSH, reduce the MDA level and inhibit lipid peroxidation.”

“That catechin-polyphenols are known to be capable of inhibiting catechol-O-methyltransferase (the enzyme that degrades norepinephrine ) is a possible explanation for why the green tea extract is effective in stimulating thermogenesis by epigallocatechin gallate to augment and prolong sympathetic stimulation of thermogenesis.”

“… catechin-polyphenols are known to be … (the enzyme that degrades NA ), and caffeine to inhibit trancellular phosphodiesterases (enzymes that break down NA-induced cAMP), it is proposed that the green … and caffeine, is effective in stimulating thermogenesis by relieving inhibition at different control points along the NA–cAMP axis.”

“A series of polyphenols have been found to reduce methylation of epinephrine and norepinephrine by O-methyl transferase in vitro, probably by acting as competitive substrates.”