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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Norepinephrine
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“However, noradrenaline (10 microM) caused significantly greater breakdown of [32P]phosphatidylinositol 4,5-bisphosphate and formation of [32P]phosphatidic acid and [3H]inositol phosphates in diabetic aortae than in control preparations.”
Enhanced arterial contractility to noradrenaline in diabetic rats is associated with increased phosphoinositide metabolism.“2 In the presence or absence of vascular endothelium, noradrenaline (NA; 5 μm) consistently reduced the amount of phosphatidylinositol 4,5‐bisphosphate (PI‐P2) and increased both phosphatidic acid (PA) and IP3.”
“ Norepinephrine stimulated the rapid hydrolysis of [3H]phosphatidylinositol-4,5-bisphosphate in rat aorta with a maximal decrease of 30% within 60 sec of stimulation.”
“Angiotensin II, noradrenaline and AGEPC caused a rapid breakdown of phosphatidylinositol 4,5-bisphosphate with a concomitant increase of 1,2-diacylglycerol and inositol trisphosphate, indicating an activation of phospholipase C by these hormones.”
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