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Last Updated: 2 years ago

Possible Interaction: Norepinephrine and Phenylalanine

Research Papers that Mention the Interaction

Furthermore, Krause et al. (4) reported an inverse relationship between NA and DA plasma concentrations and Phe because high Phe concentrations decrease the availability of the amino acids Tyr and Trp, the precursors of catecholamines and serotonin [5-hydroxytryptamine (5HT)], respectively (5)(6)(7).
High Phe concentrations interfere with the production of adrenaline (A), noradrenaline (NA), and dopamine (DA) (1)(3).
Clinical chemistry  •  2002  |  View Paper
High levels of phenylalanine (Phe) have been shown to reduce dopamine (DA) and noradrenaline (NA) production.
Clinical endocrinology  •  1998  |  View Paper
As a result of this situation, the phe levels rise up to 800–1000 μmol/L. In addition, there is some convincing evidence that the conversion of tyrosine (tyr) to melanin, dopamine and norepinephrine is decreased by high blood concentrations of phenylalanine (Nadler and Hsai, 1961).
Journal of Inherited Metabolic Disease  •  2013  |  View Paper
The impaired conversion of phenylalanine may affect not only the production of tyrosine but also the biosynthesis of the neurotransmitters dopamine, norepinephrine and epinephrine.
Journal of the Neurological Sciences  •  2013  |  View Paper
High levels of phenylalanine Phe ) in blood have been shown to reduce dopamine (DA) and noradrenaline (NA) production.
Hormone Research in Paediatrics  •  2000  |  View Paper
Tyrosine did not alter dopamine or noradrenaline levels, while phenylalanine lowered dopamine, noradrenaline and serotonin.
Psychopharmacology  •  2004  |  View Paper
Phenylalanine and its metabolite tyrosine compete with tryptophan for transport into brain, where levels of?these amino acids may influence the synthesis of the aminergic neurotransmitters norepinephrine , doparnine, and serotonin.
Annals of the New York Academy of Sciences  •  1995  |  View Paper
When norepinephrine stimulation was examined in terms of cardiocyte anabolic activity, there was a concentration-dependent decrease in the incorporation of [3H]phenylalanine and [3H]uridine into cytoplasmic protein and nuclear RNA, respectively.
Circulation  •  1992  |  View Paper
It has been suggested that aspartame facilitates seizures in man and animals because phenylalanine , one of its major metabolites, interferes with brain transport of neurotransmitter precursors and alters the synthesis of monoamine neurotransmitters such as norepinephrine , dopamine and/or serotonin.
Epilepsy Research  •  1991  |  View Paper
Preincubation of the enzyme with L-phenylalanine also leads to a complete loss of the cooperativity of L-noradrenaline binding (h = 1.0).
European journal of biochemistry  •  1990  |  View Paper
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