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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Norepinephrine
supplement:
Genistein
Research Papers that Mention the Interaction
“In addition, treatment with H-89 and either genistein or LiCl completely blocked NA stimulatory effects.”
Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).“The src kinase inhibitors genistein or PP2 normalised the increased contraction and the increased calcium release evoked by noradrenaline in cultured arteries.”
“4 Genistein but not daidzein enhanced the positive inotropic effect and the increase in Ca2+ transients induced by NE via β‐adrenoceptors, while the enhancing effect of genistein was abolished by the protein tyrosine phosphatase inhibitor vanadate.”
“In addition, genistein inhibits the negative inotropic effect of ET‐1 induced by crosstalk with NE through a PTK‐unrelated mechanism.”
“In addition, genistein could reduce the contractile responses of NA , KCl and CaCl2, and shift their cumulative concentration-response curves rightward. (”
“In calcium-free solution containing 0.01 mmol/L egtazic acid (EGTA), genistein inhibited not only the first phase contraction induced by noradrenaline (NA), but also the second contraction induced by CaCl2.”
“ Genistein , although having no effect on acute NE-induced contraction, concentration-dependently inhibited prolonged NE constriction.”
“ Genistein (1 mg/kg) and daidzein (1 mg/kg) reduced contractile response to NA in vascular tissue, but only genistein was able to inhibit hyporesponsiveness to NA, relaxation to l‐arg, increase in nitrite plasma levels, and iNOS expression produced by endotoxin.”
“Contractions induced by both noradrenaline and the alpha 2-adrenoceptor-selective agonist UK14304 (5-bromo-6-[2-imidazolin-2-yl-amino]-quinoxaline) were fully inhibited by genistein , with the latter responses being more sensitive.”
“ Genistein (10 microM) reduced the amplitude of the contraction evoked by noradrenaline (0.1-10 microM) or angiotensin II (1-100 nM).”
“The treatment with noradrenaline induced the tyrosine phosphorylation of specific substrates in lysates derived from PC Cl3 cells, an effect inhibited by genistein pretreatment.”
“The tyrosine kinases inhibitor genistein completely abolishes the plateau upon noradrenaline withdrawal.”
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