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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Norepinephrine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“The results show that ACTH can have a direct effect on transcription and gene expression of NE biosynthetic enzymes even without contribution of adrenal hormones.”
Adrenocorticotropic hormone elevates gene expression for catecholamine biosynthesis in rat superior cervical ganglia and locus coeruleus by an adrenal independent mechanism“Intracerebroventricular infusion of epinephrine and norepinephrine stimulated ACTH and prolactin secretion.”
“Cyclic AMP analogues enhance noradrenaline release and two hormones adrenaline and ACTH appear to enhance noradrenaline release through activation of adenylate cyclase.”
“Thus, ACTH increases the impulse-evoked noradrenaline ( NA ) release in the rabbit pulmonary artery by activating presynaptic ACTH receptors, and an adenylate cyclase may be involved in this effect.”
“Several known naturally occurring substances including vasopressin, oxytocin, norepinephrine , epinephrine, and angiotensin II are found to stimulate ACTH secretion.”
“Also, ACTH may play a role in the regulation of synthesis, release, uptake, and metabolism of a number of neurotransmitters, including dopamine, norepinephrine , serotonin, acetylcholine, and g-aminobutyric acid (GABA) as well as modulate binding at glutamatergic, serotinergic, muscarinic type 1, opiate, and dopaminergic receptors.”
“There was a significant increase in NE and E secretion (p less than 0.002) from both adrenal glands after ACTH stimulation.”
“ Norepinephrine appears to inhibit hypothalamic corticotropin-releasing factor, thus decreasing ACTH secretion by the pituitary and, in turn, cortisol secretion by the adrenal glands.”
“ ACTH produced a marked fall in the excretion of NE in both the hypophysectomized and the patients with idiopathic hypopituitarism and ACTH had no effect on the excretion of NE in the normal subjects.”
“ Norepinephrine sensitivity was increased in Cushing's syndrome and in patients treated with ACS and ACTH despite the absence of significant hypertension in the latter group.”
“The evidence suggests that ACTH indirectly and ACS directly may inhibit those chemical substances present in the walls of blood vessels which are responsible for inactivating norepinephrine.”
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