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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitrous Oxide
supplement:
Vitamin B Complex
Research Papers that Mention the Interaction
“In a seminal study, Amess and his colleagues (1978) showed that 24 h of administration of nitrous oxide to patients caused interference with deoxyribonucleic acid (DNA) synthesis, and they correctly inferred that nitrous oxide had interfered with the function of vitamin B,,.”
Clinical aspects of the interaction between nitrous oxide and vitamin B12.“Although vitamin B 12 becomes biologically inactive in the presence of nitrous oxide , this certainly is of no clinical consequence in exposures lasting less than eight hours.”
“ Nitrous oxide , for example, is known to inactivate vitamin B ,, by oxidation.”
“The … nitrous oxide … vitamin B , cob(1)alamin to cob(I1)alamin in vitro.2 Soon thereafter it was established that a similar reaction occurred in rats … state) was inactivated.3 Methionine synthase activity is required for the conversion of homocysteine to methionine and for the demethylation of methyltetrahydrofolate.”
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