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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitrous Oxide
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“It is suggested that N2O impairs methionine biosynthesis, methionine, in the form of S-adenosylmethionine (SAM), being required for DNA synthesis and the prevention of the development of megaloblastic anaemia in man.”
Role of S-adenosylmethionine in DNA synthesis and haemopoiesis.“S-adenosylmethionine (AdoMet) synthesis by methionine adenosyltransferase is the first step in methionine metabolism, and NO regulates hepatocyte S-adenosylmethionine levels through specific inhibition of this enzyme.”
NO sensitizes rat hepatocytes to proliferation by modifying S-adenosylmethionine levels.“ Nitrous oxide reduced S-adenosylmethionine in the brain and liver.”
“These results demonstrate that nitrous oxide can decrease the concentrations of two intermediary metabolites (methionine and S-adenosylmethionine ) that are important in the control of methylation reactions and in the maintenance of the active form of tetrahydrofolic acid.”
“ Nitrous oxide treatment inhibited hepatic methionine synthetase activity, reduced hepatic S-adenosyl- l -methionine ( Ado-Met ) and tetrahydrofolate (H4 folate) concentrations and decreased the rate of formate oxidation in the rat.”
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