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“The change in aequorin luminescence on exposure to nitrous oxide suggests that the negative inotropic effect of nitrous oxide is due to a decrease in calcium availability with no effect on myofibrillar responsiveness to calcium.”
The Journal of pharmacology and experimental therapeutics • 1991 | View Paper
“Compared with an equal concentration of nitrogen, or with pure oxygen, nitrous oxide caused a highly significant reduction in contractile force, averaging 22 per cent at 2.5 mM Ca++.”