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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitroprusside
supplement:
Vitamin C
Research Papers that Mention the Interaction
“ Vitamin C did not affect ex vivo platelet aggregability but enhanced the inhibition of platelet aggregation by SNP (62.7 ± 10.2 to 82.7 ± 4.8%, p = 0.03) and tended to increase responses to GTN (40.5 ± 9.0 to 53.4 ± 7.3, p = 0.06).”
Acute Effects of Vitamin C on Platelet Responsiveness to Nitric Oxide Donors and Endothelial Function in Patients with Chronic Heart Failure“Interestingly, administration of vitamin C to patients with MetS during hyperinsulinemia significantly enhanced the vasodilator responsiveness to acetylcholine, nitroprusside , and verapamil (all P < 0.05 vs. hyperinsulinemia alone).”
“ Ascorbic acid increased the calcium blocking effect of sodium nitroprusside and its influence on cyclic guanosine 3'-5'-monophosphate content, but did not alter the inhibitory effect of nitroglycerin.”
“ Ascorbic acid increased the calcium blocking effect of NP but did not influence the inhibitory effect of GTN.”
“L-NAME significantly inhibited ethanol-induced release of AA, while SNP only had a transient inhibitory effect on the ethanol-induced release of AA.”
Role of nitric oxide in ethanol-induced ascorbic acid release in striatum of freely moving mice.“ Vitamin C inhibited relaxation to GTN but potentiated relaxations to NP and SNAP, causing a parallel shift to a lower concentration range of the log dose‐response curve by approximately one log unit at the highest dose.”
“ Vitamin C potentiates relaxation to the NO‐donors NP and SNAP by a mechanism that could involve release of NO from nitrosothiols.”
“Cotreatment of lead with vitamin C (3 mmol/L) prevented the increase on mean arterial BP, improved the relaxation to both acetylcholine and sodium nitroprusside , and restored the normal expression of endothelial NO synthase and sGC proteins in the vascular wall.”
“ Ascorbic acid concentration increased at the end of SNP infusion.”
“In addition, SNP decreased ascorbic acid and L‐DOPA but increased uric acid concentration in the dialysate.”
“ AA (10(-5) to 10(-3) M) had no effect on basal LH-RH release but completely blocked high [K(+)]- and nitroprusside-induced LH-RH release.”
“ Sodium nitroprusside , which releases NO, stimulated LH-RH release and decreased the concentration of AA in the incubation medium, presumably because the NO released oxidized AA to dehydro-AA.”
“ AA enhanced SNP toxicity, but it reduced toxicity of NMDA.”
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