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“Pre-treatment with 10 microM SNP increased the proline accumulation in Cu-treated cells by about 1.5-fold, while this effect could be blocked by addition of 10 microM cPTIO.”
“Also, the up regulation of △1-pyrroline-5-carboxylate synthetase (P5CS) and ornithine d-aminotransferase (OAT) and down regulation of proline dehydrogenase (PDH) were induced by SNP treatment, thereby accelating proline production.”