Possible Interaction: Nitroprusside and Iron, Dietary

“Downstream effects of iron , after being dissociated from SNP , include increases in intracellular cAMP that are causally linked to subsequent phosphorylation of specific MAPK targets and enhanced HO-1 protein levels.”

“Our results showed that sodium nitroprusside inhibited sperm motility and motion kinematics in a dose‐dependent manner by significantly enhancing intracellular iron and reactive oxygen species (ROS), and decreasing Ca2+, and adenosine triphosphate levels in spermatozoa.”

“Overall, our results indicate that the potential of SNP to increase iron ions and ROS should be especially considered for some biological functions and, possibly, also for clinical applications of this drug.”

“ SNP induced a marked increase in iron ions , superoxide anion (O2(•-)), hydrogen peroxide (H2O2) and hydroxyl radical ((•)OH) level.”

“All compounds, except C-4 and C-6 significantly inhibited Fe (II) and sodium nitroprusside ( SNP ) induced thiobarbituric acid reactive species (TBARS) production in rat's brain, liver and kidney preparations with highest activity observed for C-2.”

“We tested our hypothesis that iron may contribute more to the SNP induction of HO-1 than does NO by comparing the HO-1 protein level and the production of NO in RAW 264.7 cells treated with SNP and S-nitroso-N-acetyl-dl-penicillamine (SNAP).”

“ SNP affects plant growth by modulating proteome though iron , cyanide and NO.”