Possible Interaction: Nitroprusside and Ascorbate

“The pretreatment of the cell with SNP along with ascorbate , methylene blue, or superoxide dismutase attenuated the induction of function and expression for P-glycoprotein, suggesting that the reaction product between superoxide and NO is involved in the induction of function and expression.”

“There was a trend for further impairment of dopamine neuron survival, to only 7% of untreated control, when the cultures were treated with SNP plus ascorbate , i.e. when the nitric oxide radical (NO) had presumably been formed.”

“ Sodium nitroprusside (SNP) reduced with 0.4 mM ascorbate (SNP/Vc) significantly increased Lactate dehydrogenase (LDH) efflux in a concentration-dependent manner.”

“Posterior chamber aqueous humor ascorbate concentration was decreased in the eye receiving the NaN3 or SNP.”

“Both the KNO3 and the SNP treatments increased reduced ascorbate (ASC) concentrations, which reached control values in the presence of cPTIO.”

“Moreover, SNP treatment also upregulated the transcript levels of CAT, POD, ascorbate peroxidase, glutathione reductase and superoxide dismutase genes in shoots under Ni-stress.”

“ SNP also boosted antioxidant capacity in Ni-stressed plants by maintaining increased levels of ascorbate , enhanced activities of ROS-detoxifying enzymes, particularly peroxidase (POD) and catalase (CAT) in both roots and shoots compared with Ni-stressed alone plants.”

“Addition of SA, SNP and SA + SNP interestingly reduced root-to-shoot translocation of zinc and increased significantly the level of glutathione (GSH) and ascorbate (ASC) in leaves of Zn-stressed plants.”

“The two ionized forms of ascorbate present in aqueous solution reduce SNP in the order A2->>HA->>H2A (H2A=L-ascorbic acid) to release NO.”