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Last Updated: 3 years ago

Possible Interaction: Nitroglycerin and Vitamin E

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drug:

Nitroglycerin

supplement:

Vitamin E

Research Papers that Mention the Interaction

“Continuous NTG infusion induced nitrate tolerance in rats after 48 h, and vitamin E concentrations decreased in a time-dependent manner in tissues and plasma.”

“ Vitamin E supplementation inhibited nitrate tolerance 48 h after NTG infusion.”

Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress.

Free radical biology & medicine • 2006 | View Paper

“ Glyceryl trinitrate increased the mutation frequency in MN-11 tumors, and vitamin E reduced the median frequency by 61.4% (P: =.058).”

Effect of dietary vitamin E on spontaneous or nitric oxide donor-induced mutations in a mouse tumor model.

Journal of the National Cancer Institute • 2000 | View Paper

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