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Last Updated: 2 years ago

Possible Interaction: Nitroglycerin and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

The data of clinic observation and ECG-monitoring show that ascorbic acid significantly increases antianginal vasodilatory effects of nitroglycerine thus preventing from development of ischemic miocardial reaction in response to complamin injection.
Klinicheskaia meditsina  •  2002  |  View Paper
Vitamin C did not affect ex vivo platelet aggregability but enhanced the inhibition of platelet aggregation by SNP (62.7 ± 10.2 to 82.7 ± 4.8%, p = 0.03) and tended to increase responses to GTN (40.5 ± 9.0 to 53.4 ± 7.3, p = 0.06).
Journal of cardiovascular pharmacology  •  2001  |  View Paper
Vitamin C failed to restore either the hemodynamic or venous effects of NTG.
Journal of cardiovascular pharmacology  •  1999  |  View Paper
Vitamin C inhibited relaxation to GTN but potentiated relaxations to NP and SNAP, causing a parallel shift to a lower concentration range of the log dose‐response curve by approximately one log unit at the highest dose.
British journal of pharmacology  •  2002  |  View Paper
Pretreatment with 30 mg/kg vitamin C led to a significant decrease in CP formation: 0.27+/-0.14 microM (vitamin C plus GTN ) and 0.34+/-0.15 microM (vitamin C plus PETN).
Free radical biology & medicine  •  1999  |  View Paper
Coadministration of carvedilol metabolite BM910228 or of Vit-C along with GTN suppressed noxious effects of GTN-induced oxidant stress such as increased platelet activity and impaired nitrate-induced vasorelaxation.
The basal cyclic guanosine monophosphate (cGMP) contents of platelets after GTN coadministered with BM910228 or with Vit-C increased on day 1 to 233 or to 250% versus control and remained at that level.
Journal of cardiovascular pharmacology  •  1999  |  View Paper
Cyclic GMP stimulation by GTN was up to 3.1‐fold higher when vitamin C (1–10 mM) was present during the pretreatment period.
FEBS letters  •  1998  |  View Paper
During nonintermittent PETN and during GTN with additional vitamin C , a 9.8 +/- 0.4% coronary artery dilation was observed in contrast to that with GTN alone, which resulted in complete tolerance at day 4.
Journal of cardiovascular pharmacology  •  1997  |  View Paper
Ascorbic acid prevented inactivation of XO, resulting in increased NO production from GTN.
Front. Pharmacol.  •  2018  |  View Paper