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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitroglycerin
supplement:
Methionine
Research Papers that Mention the Interaction
“Thus, methionine potentiates the venodilative effect of sublingual nitroglycerin both immediately and in the setting of nitrate tolerance.”
Methionine restores the venodilative response to nitroglycerin after the development of tolerance.“Methionine alone induced no hemodynamic effects, but after methionine infusion, there was a significant reduction in the nitroglycerin infusion rate required to reach each hemodynamic endpoint (p less than 0.01).”
“This study was performed to assess whether methionine , an amino acid capable of increasing sulfhydryl availability, would potentiate the hemodynamic effects of nitroglycerin.”
“Thus, methionine potentiates the hemodynamic effects of acutely administered intravenous nitroglycerin.”
“Similarly, the thiol donor L-methionine significantly increased RTCS sensitivity to GTN , as the relaxation EC50 decreased from the control value of 0.25 +/- 0.08 microM to 10 +/- 4 nM (n = 5, p < 0.001), whereas the D-isomer did not.”
Thiol agents potentiate glyceryl trinitrate mediated relaxation of rabbit taenia coli: evidence for thiol-dependent biotransformation.“Methods and ResultsIn awake nontolerant dogs, L-methionine (100 mg/kg) potentiated the tachycardic response to GTN (5.0 and 15 μg/kg/min) and enhanced the hypotensive action of GTN (1.5 and 5.0 μg/kg/min) in anesthetized, nonreflexic dogs.”
“Pretreatment of tissues with FK409 (10-6 M ) inhibited the relaxing action of NG much more than prior NG inhibited the relaxing action of FK409.”
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