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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Nitroglycerin and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

In rat aortic rings, genistein (10(-5) M and 3x10(-5) M), a tyrosine kinase inhibitor, but not daidzein, an analogue of genistein, increased relaxation induced by nitroglycerin in a concentration-dependent manner.
These results suggest that, in the rat aortic rings, genistein inhibits cyclic AMP-dependent phosphodiesterase activities, resulting in the increase of the relaxation induced by nitroglycerin.
European journal of pharmacology  •  1999  |  View Paper