Possible Interaction: Nitroglycerin and Calcium Supplement

“The study demonstrated a dose-dependent inhibitory effect of nitroglycerin on calcium rise, induced by ADP.”

“ Nitroglycerin suppressed the Mn2+ entry into the cells and caused a 2-fold increase of the cGMP content which correlates with the calcium blocking activity.”

“Both verapmil and nitroglycerin inhibited the contractile responses to calcium ; the inhibiting effects of verapamil were significantly more marked than those of nitroglycerin.”

“Results: NG administration resulted in dose-dependent short-term increase in Ca2+ -uptake accompanied by essential rise in L-citrulline and RNS content in mitochondria.”

“It is shown that NG administration results in a dose-dependent increase in Ca2+ -uptake in mitochondria, due to the dose-dependent inhibition of mitochondrial permeability transition pore (MPTP) in vivo and the activation of Ca2+-dependent mitochondrial NOS.”

“ Calcium increased repolarization heterogeneity (interlead precordial T-wave heterogeneity, 95 ± 15 to 264 ± 33 μV, P < 0.006; Tpeak−Tend, an index of … to 76 ± 6 ms, P < 0.05) and lowered repetitive extrasystole threshold (RET; 24 ± 2 to 13 ± 1 mA, and following NTG , 32 ± 4 … < 0.0001).”

“In vitro, on the contrary, a concentration-dependent decrease in Ca2+ -uptake caused by NG as well as SNP is observed together with simultaneous decrease of deltapsim and concentration-dependent release of Ca2+ from mitochondria via Ca2+-uniporter as the result of partial depolarisation of mitochondrial inner membrane.”

“ Nitroglycerin (10-5 M) had no effect on responses to potassium (10–70 mM), but slightly inhibited responses to Ca2+ (0.1–5 mM) in a Ca2+-free medium containing potassium.”

“The data suggest that positive inotropic action of nitroglycerin depends upon transsarcolemmal influx of calcium ions and is partially associated with the stimulation of myocardiac beta-receptors.”

“DZ primarily blocks the influx of Ca++ from the extracellular space, whereas GTN appears to act by inhibiting Ca++ movements at an intracellular site.”