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“When added 5 min before L-glutamate and just after L-glutamate removal and kept in contact with neurons for the following 24 h, NG-nitro-L-arginine (100 microM) antagonized by 74% the L-glutamate-induced neurotoxicity.”
“This effect of L-glutamate was reduced by prior intra NRM administration of NO synthase inhibitor NG-methyl-L-arginine or NG-nitro-L-arginine methyl ester (L-NAME, 0.1 µl, 100 nM).”