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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Nitric Oxide
supplement:
Xanthohumol
Research Papers that Mention the Interaction
“The results showed that XN has the capability to hinder the expression of nitric oxide synthase (INOS), IL-1β-promoted inducible nitric oxide ( NO ), necrosis factor-α of tumor (TNF-α), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in vitro.”
Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice.“The chalcones, including xanthohumol , significantly inhibited the production of NO by suppressing the expression of iNOS.”
“Moreover, XN is able to scavenge reactive oxygen species, including hydroxyl- and peroxyl radicals, and to inhibit superoxide anion radical and nitric oxide production.”
“In this article, we found that XH significantly inhibited inflammatory responses, attenuated catabolic enzymes expression, and ameliorated ECM degradation, as showed by decreased production of NO , PGE2, TNFα, and IL-6, decreased expression of MMP-3/-13 and ADAMTS-4/-5, and increased expression of collagen-II and aggrecan.”
Xanthohumol Attenuated Inflammation and ECM Degradation by Mediating HO-1/C/EBPβ Pathway in Osteoarthritis Chondrocytes
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