Possible Interaction: Nitric Oxide and Vitamin E

“Changes in both plasma sVCAM-1 and NO metabolite levels showed a trend to significantly correlate (r = -0.515, P = 0.010; and r = 0.435, P = 0.034, respectively) with changes in vitamin E concentrations induced by vitamin E supplementation.”

“The use of vitamin E as an anti-oxidant might enhance the bioavailability of nitric oxide in this situation.”

“Antioxidants, such as melatonin, vitamin C, and vitamin E , probably play important roles in reducing or eliminating the oxidant damage produced by NO.”

“Later, alpha-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages.”

“In addition, L-arginine, the substrate for NO synthesis, and the anti-oxidants ascorbate and α-tocopherol , are able to increase NO synthesis and bioavailability respectively.”

“Antioxidants, such as melatonin, vitamin C, and vitamin E , probably play an important acute and chronic role in reducing or eliminating the oxidant damage produced by NO.”

“CONCLUSION Co-supplementation with omega-3 FAs and vi amin E in creases the levels of NO an d TAC, while MDA levels decrease compared to placebo.”

“ Vitamin E increased the effect of acetylsalicylic acid on neutrophil nitric oxide production 42-fold (P < 0.05).”

“A reduction of NO bioavailability leads to endothelial dysfunction that has been shown to be improved by alpha-tocopherol in certain conditions.”

“Our data suggest that vasoprotective effects of alpha-tocopherol in vivo may be related to an increase of NO formation.”

“Antioxidants, such as vitamin C and vitamin E , probably have an important role in reducing the oxidative damage produced by nitric oxide and other free radicals and improving the ocular surface milieu.”