Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Nitric Oxide and Vitamin E

supplement:

Vitamin E

Research Papers that Mention the Interaction

Changes in both plasma sVCAM-1 and NO metabolite levels showed a trend to significantly correlate (r = -0.515, P = 0.010; and r = 0.435, P = 0.034, respectively) with changes in vitamin E concentrations induced by vitamin E supplementation.
The Journal of clinical endocrinology and metabolism  •  2002  |  View Paper
The use of vitamin E as an anti-oxidant might enhance the bioavailability of nitric oxide in this situation.
Atherosclerosis  •  1999  |  View Paper
Antioxidants, such as melatonin, vitamin C, and vitamin E , probably play important roles in reducing or eliminating the oxidant damage produced by NO.
Annals of the New York Academy of Sciences  •  2005  |  View Paper
Later, alpha-tocopherol was shown to inhibit PKC in various cell types with consequent inhibition of aggregation in platelets, of nitric oxide production in endothelial cells and of superoxide production in neutrophils and macrophages.
FEBS letters  •  2002  |  View Paper
In addition, L-arginine, the substrate for NO synthesis, and the anti-oxidants ascorbate and α-tocopherol , are able to increase NO synthesis and bioavailability respectively.
Expert opinion on pharmacotherapy  •  2001  |  View Paper
Antioxidants, such as melatonin, vitamin C, and vitamin E , probably play an important acute and chronic role in reducing or eliminating the oxidant damage produced by NO.
Experimental Gerontology  •  1998  |  View Paper
Vitamin E increased the effect of acetylsalicylic acid on neutrophil nitric oxide production 42-fold (P < 0.05).
Platelets  •  2005  |  View Paper
A reduction of NO bioavailability leads to endothelial dysfunction that has been shown to be improved by alpha-tocopherol in certain conditions.
Our data suggest that vasoprotective effects of alpha-tocopherol in vivo may be related to an increase of NO formation.
Annals of the New York Academy of Sciences  •  2004  |  View Paper
Antioxidants, such as vitamin C and vitamin E , probably have an important role in reducing the oxidative damage produced by nitric oxide and other free radicals and improving the ocular surface milieu.
The British journal of ophthalmology  •  2002  |  View Paper
In animal models of endothelial dysfunction, vitamin E improved the activity of endothelium-derived nitric oxide , and this effect was not dependent upon the antioxidant protection of LDL.
The Journal of nutrition  •  2001  |  View Paper
Show More