Possible Interaction: Nitric Oxide and Vitamin D

“Data from in vitro and animalmodel studies confirm that vitamin D induces an increase in the amount of nitric oxide released by the endothelium, an inhibition of the aggregation and adhesion of platelets and leukocytes, a reduction of oxidative stress, a relaxation of vascular muscle tone,”

“In endothelial cells, vitamin D regulates NO synthesis by mediating the activity of the endothelial NO synthase (eNOS).”

“Recently, however, vitamin D has been shown to induce endothelial cell expression of nitric oxide (NO) synthase, resulting in increased production of the vasodilator, NO [5].”

“Conclusion The significantly inverse association of NOx and 25(OH)D among apparently healthy adolescents is influenced by sex and further strengthens the extraskeletal role of 25(OH)D in maintaining endothelial homeostasis in this age group, particularly in boys.”

“In all subjects, NOx showed a significant inverse correlation with 25(OH)D. After stratification according to sex however this significant association was observed only in boys and not in girls.”

“ Vitamin D has been shown to induce nitric oxide synthesis in the macrophages, suppressing intracellular M. tuberculosis growth.”

“Overall, this meta-analysis shows that in diabetic patients, taking vitamin D had significant effects on hs-CRP and MDA levels, and significantly increased NO , TAC and GSH levels.”

“…,vitamin D supplementation were found … nitric oxide ( NO ) release (WMD 4.33, 95% CI 0.96, 7.70), total serum antioxidant capacity (TAC) (WMD 57.34, 95% CI 33.…, p<0.001) and total glutathione (GSH) levels (WMD 82.59, 95% CI 44.37, 120.81, p<0.001).”

“In inactive BD, vitamin D levels correlates negatively with NO.”

“Interestingly, vitamin D3 inhibits ex vivo NO production, iNOS and NF-κB expression in BD patients.”

“Recent studies have postulated a role for vitamin D and its receptor … function, and anti‐inflammatory, immunomodulatory and neuroprotective effects have been described; vitamin D can inhibit … cytokines and nitric oxide synthesis during various neurodegenerative insults, and may be considered … a potential drug for the treatment of these disorders.”

“However, significant results in terms of mean NOx concentration were observed in the comparison of normal and deficient vitD OA groups (P = 0.048).ConclusionResults suggest that vitD increases NO production and inducible NO synthase expression in osteoarthritic chondrocytes possibly leading to a protective effect.”

“ NO notably decreased with decreasing 25(OH)D concentration in patients.”

“Indeed, in cardiac and endothelial cells, Q10, L-arginine, and vitamin D3 combined were able to induce a nitric oxide production higher than the that induced by the 3 substances alone.”