Possible Interaction: Nitric Oxide and Vitamin C

“We tested the hypothesis that in HF, endogenous nitric oxide (NO) opposes the positive effect of vitamin C on adrenergically stimulated contractility by examining the effects of vitamin C on dobutamine responses during NO synthase inhibition.”

“Diet supplementation with vitamin C reduced neutrophil iNOS levels and NO production.”

“The antioxidant vitamin C increases nitric oxide bioavailability in CHF.”

“In patients with CHF acute intravenous administration of vitamin C enhances platelet responsiveness to the anti-aggregatory effects of NO donors and improves endothelial function, suggesting a potential role for vitamin C as a therapeutic agent in CHF.”

“ EDNO action is improved by administration of ascorbic acid , a water-soluble antioxidant.”

“Pharmacologic studies reveal that vitamin C (as ascorbate), at supraphysiologic doses, significantly affects the bioavailability of nitric oxide during acute inflammation, including inhibiting nitric oxide synthetase induction.”

“The inhibition of leptin-mediated STAT3 phosphorylation caused by excessive NO was partially prevented by a sulfhydryl reducing agent, ascorbic acid.”

“Antioxidants, such as melatonin, vitamin C , and vitamin E, probably play important roles in reducing or eliminating the oxidant damage produced by NO.”

“The increase in O2.- and the reduction of NO were inhibited by the presence of vitamin C and anti-LOX-1 monoclonal antibody (p < 0.001).”

“Co‐incubation with redox compounds, N‐acetyl‐L‐cysteine, glutathione and L‐ascorbic acid prevented NO inhibition of DNA synthesis.”