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Last Updated: 2 months ago

Possible Interaction: Nitric Oxide and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

We tested the hypothesis that in HF, endogenous nitric oxide (NO) opposes the positive effect of vitamin C on adrenergically stimulated contractility by examining the effects of vitamin C on dobutamine responses during NO synthase inhibition.
American journal of physiology. Heart and circulatory physiology  •  2005  |  View Paper
Diet supplementation with vitamin C reduced neutrophil iNOS levels and NO production.
Free radical biology & medicine  •  2004  |  View Paper
The antioxidant vitamin C increases nitric oxide bioavailability in CHF.
Clinical science  •  2003  |  View Paper
In patients with CHF acute intravenous administration of vitamin C enhances platelet responsiveness to the anti-aggregatory effects of NO donors and improves endothelial function, suggesting a potential role for vitamin C as a therapeutic agent in CHF.
Journal of cardiovascular pharmacology  •  2001  |  View Paper
EDNO action is improved by administration of ascorbic acid , a water-soluble antioxidant.
The Journal of clinical investigation  •  1998  |  View Paper
Pharmacologic studies reveal that vitamin C (as ascorbate), at supraphysiologic doses, significantly affects the bioavailability of nitric oxide during acute inflammation, including inhibiting nitric oxide synthetase induction.
Critical care medicine  •  2007  |  View Paper
The inhibition of leptin-mediated STAT3 phosphorylation caused by excessive NO was partially prevented by a sulfhydryl reducing agent, ascorbic acid.
Life sciences  •  2007  |  View Paper
Antioxidants, such as melatonin, vitamin C , and vitamin E, probably play important roles in reducing or eliminating the oxidant damage produced by NO.
Annals of the New York Academy of Sciences  •  2005  |  View Paper
The increase in O2.- and the reduction of NO were inhibited by the presence of vitamin C and anti-LOX-1 monoclonal antibody (p < 0.001).
Journal of the American College of Cardiology  •  2003  |  View Paper
Co‐incubation with redox compounds, N‐acetyl‐L‐cysteine, glutathione and L‐ascorbic acid prevented NO inhibition of DNA synthesis.
British journal of pharmacology  •  2000  |  View Paper
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