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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“The neurological lesions were undoubtedly induced by nitrogen protoxide via an inactivation of vitamin B12.”
[Postoperative combined medullary sclerosis revealing Biermer's disease: toxic effect of nitrous oxide].“Since NO is known to interact with cobalamin (vitamin B12), 4 a known cofactor in the methyl transfer reaction, we argued that the effect of NO on the methyl group transfer reaction may be a result of sequestration of this cofactor by NO.”
“These effects of NO can be effectively alleviated by FA or vitamin B12.”
Folic acid rescues nitric oxide-induced neural tube closure defects“The interaction with nitric oxide NO ) is an important aspect of the biological activity of vitamin B12 (Cbl).”
Mechanistic information on the nitrite-controlled reduction of aquacob(III)alamin by ascorbate at physiological pH“Despite early claims that nitric oxide does not react with cobalamin under any circumstances, it is now accepted that NO has a high affinity for cobalamin in the 2+ oxidation state [Cbl(II)].”
“Electrochemistry and Raman spectroscopy have shown that aquocob(III)alamin (Cbl(III)) can be reduced by nitric oxide (NO) to form Cbl(II) on an electrode surface.”
“These results can be used to explain a number of physiological effects involving NO interaction in biological systems with added cobalamin or with cobalamin in the methionine synthase enzyme.”
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