Possible Interaction: Nitric Oxide and Tyrosine

“Taken together, these observations suggest that NO modulates tyrosine phosphorylation in HER14 cells.”

“We hypothesized that NO or derivative reactive nitrogen species may generate adducts of tyrosine and/or cysteine residues, causing CYP2B6 downregulation, and selected Tyr and Cys residues for mutation based on predicted solvent accessibility.”

“ NO promotes Akt-dependent phosphorylation of Cav-1 at tyrosine 14 , disrupting the Cav-1:Oct4 complex.”

“PA attenuated insulin-mediated insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation, leading to decreased glucose uptake, and phosphorylation of eNOS, leading to a reduction in the production of NO.”

“We demonstrate further that NO may exert its inhibitory effects by influencing matrix metalloproteinase expression/activity and tyrosine phosphorylation of proteins in the sprouting tips of nascent capillaries.”

“Moreover, nitric oxide modulated tyrosine phosphorylation of sperm proteins.”

“Peroxynitrite, but not nitric oxide , reacts with the phenolic ring of tyrosine to form the stable product 3-nitro-L-tyrosine.”

“We found that the NO coordination state, NO dissociation, and enzyme activation were significantly affected by the presence of a tyrosine in the distal heme pocket; however, the stability of the reduced porphyrin and the proteins affinity for oxygen were unaltered.”

“Increased nitric oxide (NO) results in increased nitration of proteins at tyrosine , which can cause protein dysfunction or alterations in signal transduction pathways.”

“Analysis of T cell lysates by immunoprecipitation with specific Abs and subsequent immunoblotting indicated marked reduction of tyrosine phosphorylation of Jak3 and STAT5 mediated by NO.”