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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Tryptophan
Research Papers that Mention the Interaction
“Importantly, NO∙ suppresses the activity of the heme enzyme IDO-1, which could explain the higher tryptophan levels.”
Tryptophan Metabolism in Allergic Disorders“Exposure of intact IFN gamma-primed human peripheral blood mononuclear cells or monocyte-derived macrophages … of the NO-generating compounds, sodium nitroprusside, glyceryl trinitrate, S-nitroso-N-acetylpenicillamine, or diethylamine dinitric oxide adduct, resulted in inhibition … the consumption of tryptophan from and formation of its …, in the culture medium.”
“ TRP absence inhibited nitric oxide synthase activity in a ROS-dependent way, whereas it increased the expression of ICAM-1 and VCAM-1 in a ROS independent and possibly p53-dependent manner.”
“The promotion of H2O2 consumption by peroxidase substrates, NO consumption, and IDO nitration was inhibited by l-Trp.”
“Among EleAA, Lys, Trp , His, and Arg (4AA) markedly decreased nitric oxide production and inhibited nuclear factor-κB (NF-κB) activation.”
Elental® amino acid component has protective effects on primary cultured hepatocytes and a rat model of acute liver injury.“This may be due to the fact that some amino-acids (arginine and tryptophan ) may influence bioavailability of NO.”
CO-07: Prognostic value of protein intake assessed by 24-hour urinary excretion in hypertension.“The administration of L- Trp also significantly increased plasma nitric oxide and serotonin levels.”
“ NO can be selectively photodissociated from only one of the heme-NO sites and only in the presence of L-Trp.”
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