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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Trypsin
Research Papers that Mention the Interaction
“The NOS expression and NO production of LSECs during hypothermia and hypoxia-reoxygenation were inhibit by alpha-1 trypsin dose-dependently.”
[Protection of liver sinusoidal endothelial cells from hypoxia-reoxygenation induced apoptosis by alpha-1 antitrypsin in vitro].“These results suggest that trypsin increases [Ca(2+)](i) in the endothelial cells through SKF-96365-insensitive Ca(2+) channels and regulates the release of NO , which results in relaxation of the rat aorta.”
Effects of trypsin on cytosolic calcium levels in the rat aortic endothelium.“Treatment of PAR-2 agonist trypsin increased NO production in a dose-dependent manner, which was mediated by the induction of inducible nitric-oxide synthase.”
“Results The results showed that trypsin concentration up to 20 U/ml caused a significant increase in NO , in a dose-dependent manner, on cultured astrocytes (P < 0.001).”
“ Trypsin 20 U/ml increased NO production fivefold the control group (P < 0.001).”
The effects of trypsin on rat brain astrocyte activation“ Nitric oxide also enhances the radiosensitivity of dry trypsin , but to a lesser extent.”
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