Possible Interaction: Nitric Oxide and Tretinoin

“ ATRA down-regulates NO production in BD patients.”

“We observed that ATRA inhibits NO production in BD both in active and inactive stages and inhibits NF-κB translocation.”

“Recent studies suggest retinoids may also be involved in vascular calcification and endothelial function, for example, by modulating nitric oxide pathways.”

“We noticed that while IL-6 induced a high NO production and iNOS expression, ATRA downregulated both.”

“Remarkably, ATRA treatment showed an important downregulatory effect on NO production and iNOS expression in patients.”

“ t-RA potently suppressed IL-1-induced expression of iNOS and COX-2 and production of nitric oxide and prostaglandin E2.”

“ ATRA significantly increased their basal as well as acetylcholine-induced NO production.”

“Conclusions ATRA increases NO production by eNOS phosphorylation through RAR-mediated PI3K/Akt pathway activation in vascular ECs and possibly plays beneficial roles in vascular endothelium.”

“During neurulation, NO modulates RA production through the transcriptional regulation of Aldh1a.2 that irreversibly converts retinaldehyde into RA.”

“Here, we demonstrate the functional cooperation between NO and RA that occurs during amphioxus embryogenesis.”

“This reciprocal regulation of NO and RA pathways is essential for the normal pharyngeal development in amphioxus and it could be conserved in vertebrates.”

“In the ATRA-experiment, ATRA suppressed the secretion of IL-6 and NO , downregulated the NF-κB P65 and Bcl-2, increased levels of autophagy marker protein LC3, but different doses of ATRA showed inconsistent regulatory effects on VEGF and MMP-9.”

“In the ATRA-experiment, ATRA suppressed the expression of IL-6, TNF-α, NO , a disintegrin and metalloprotease with thrombospondin motifs-4 (ADAMTS-4), MMP-3, and MMP-9.”

“Therefore, the present study demonstrated that ATRA may regulate the grade of AS by the reduction of ET‑1 secretion and increased NO formation via increased phosphorylation of eNOS.”