Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Nitric Oxide and Tretinoin



Research Papers that Mention the Interaction

ATRA down-regulates NO production in BD patients.
We observed that ATRA inhibits NO production in BD both in active and inactive stages and inhibits NF-κB translocation.
Immunopharmacology and immunotoxicology  •  2014  |  View Paper
Recent studies suggest retinoids may also be involved in vascular calcification and endothelial function, for example, by modulating nitric oxide pathways.
Biochimica et biophysica acta  •  2012  |  View Paper
We noticed that while IL-6 induced a high NO production and iNOS expression, ATRA downregulated both.
Immunopharmacology and immunotoxicology  •  2017  |  View Paper
Remarkably, ATRA treatment showed an important downregulatory effect on NO production and iNOS expression in patients.
Neuroimmunomodulation  •  2015  |  View Paper
t-RA potently suppressed IL-1-induced expression of iNOS and COX-2 and production of nitric oxide and prostaglandin E2.
Immunological investigations  •  2008  |  View Paper
ATRA significantly increased their basal as well as acetylcholine-induced NO production.
Conclusions ATRA increases NO production by eNOS phosphorylation through RAR-mediated PI3K/Akt pathway activation in vascular ECs and possibly plays beneficial roles in vascular endothelium.
Circulation  •  2005  |  View Paper
In the ATRA-experiment, ATRA suppressed the expression of IL-6, TNF-α, NO , a disintegrin and metalloprotease with thrombospondin motifs-4 (ADAMTS-4), MMP-3, and MMP-9.
Journal of nutritional science and vitaminology  •  2019  |  View Paper
Therefore, the present study demonstrated that ATRA may regulate the grade of AS by the reduction of ET‑1 secretion and increased NO formation via increased phosphorylation of eNOS.
Molecular medicine reports  •  2018  |  View Paper
The eNOS activity and NO level were reduced in the AS group, however were notably increased following oral administration of ATRA.
Molecular medicine reports  •  2018  |  View Paper
We previously showed that all-trans retinoic acid (atRA) decreased nitric oxide (NO) production through Akt-mediated decreased phosphorylation of endothelial NO synthase at serine 1179 (eNOS-Ser(1179)) in bovine aortic endothelial cells (BAEC).
Biochemical and biophysical research communications  •  2013  |  View Paper
Show More