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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Nitric Oxide
supplement:
Tocopherols
Research Papers that Mention the Interaction
“ Mixed tocopherols were more potent than alpha-tocopherol alone in modulating NO release and ecNOS activation but not SOD protein content or PKC activation.”
Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms.“TS enhanced the amount of protein kinase Cα (PKCα) in VSMC, and PKC inhibitors inhibited TS-enhanced NO production, suggesting that the enhancing effect of TS on NO production is caused by up-regulation of PKC.”
“The enhancement by TS of NO production was inhibited by α-T but not by antioxidants such as ascorbic acid and 2[3]-t-butyl-4-hydroxyanisole (BHA).”
“Results of the current study suggest that NO is an important mediator of damage within the cell, as well as in the oxidation of both α- and γ-tocopherols.”
Enhancement of intracellular γ-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis, isoprostane formation, and tocopherol oxidation“The mutagenic activity of NO was most effectively inhibited by beta-carotene and tocopherols.”
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