Possible Interaction: Nitric Oxide and Taurine

“The pre- …/or TAU significantly depressed CCl 4 -induced elevation of alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, gamma-glutamyl transferase, total bilirubin, direct bilirubin, indirect bilirubin, …, and γ), albumin/globulin ratio, triglycerides, total cholesterol, high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, nitric oxide, ….”

“Furthermore, taurine and taurine-conjugated BAs might regulate NO synthesis and activity by enhancing H2S generation.”

“However, in the presence of cardiometabolic risk factors, it has been proposed that taurine can increase vascular NO levels by increasing eNOS expression, eNOS phosphorylation on Ser1177, NO bioavailability, the level of antioxidative defense, and the l-arginine/NOS inhibitor asymmetric dimethylarginine (ADMA) ratio.”

“ Taurine (1 or 5 microg/ml) significantly attenuated the increases in the levels of LDH, ADMA, TNF-alpha and MDA, and the decrease in the level of NO and the activity of DDAH induced by ox-LDL in HUVECs.”

“Treatment with taurine in vivo (60 or 180 mg/kg) significantly attenuated the inhibition of endothelium-dependent vasorelaxation and the reduced level of NO , and decreased the elevated levels of ADMA, MDA, and TNF-alpha.”

“ Nitric oxide also modulates taurine release, enhancing the basal release in both immature and mature hippocampus, whereas the K(+)-stimulated release is generally inhibited.”

“Inhibition of NO synthesis by taumine alone is indeed a favorable situation, but it is conceivable that shunting of taurine into this pathway may reduce levels available for HOC1 sequestration.”

“It has been demonstrated that taurine can stimulate testosterone secretion, increase nitric oxide synthase (NOS) activity and nitric oxide (NO) production, and reduce blood glucose levels in the diabetic animals.”

“ Taurine supplementation improved the relaxation response to acetylcholine and eNOS-derived NO production, increased EC-SOD and p-eNOS protein expression, as well as reduced ROS generation and p47phox expression in the aortas from LPT rats.”

“The levels of serum LH, T, NOS, and NO were found to be obviously increased by taurine supplementation in aged rats in our previous study.”

“The results indicated that taurine can enhance the sexual response and mating ability in aged male rats by increasing the level of testosterone and NO , but the exact mechanism of which needs to be further investigated.”

“2) Primary cultured mouse mammary epithelial cells were treated with 0, 5, 15 or 45 … taurine for 3 h, followed by 10 μg/mL LPS for 24 h. Taurine significantly attenuated the LPS-… in NAGase activity, NO concentrations and the level of TNF-…, IL-1β, IL-6 and LF.”

“It was determined that taurine treatment decreased the levels of 3-nitrotyrosine and NOx in taurine+endotoxemia group.”

“The group in which taurine was administered alone, contradiction to well-known antioxidant effect, taurine caused elevated concentration of 3-NT and NOx.”