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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
St John's Wort
Research Papers that Mention the Interaction
“In conclusion, SJW counteracted the NO donor-induced pain hypersensitivity and meningeal activation by blocking PKC-mediated pathways involving NF-κB, CREB, STAT1.”
St. John's wort reversal of meningeal nociception: a natural therapeutic perspective for migraine pain.“ NO donors increased expression and phosphorylation of protein kinase C (PKC) γ and ε isoforms, molecular events prevented by SJW or hypericin.”
“We found … extracts of St. John’s wort efficiently suppress …-induced NO release and identified hyperforin as the responsible compound, being effective at concentrations between 0.25 and 0.75 µM. … reduced NO production was mediated by diminished inducible nitric oxide synthase expression on the mRNA and protein level.”
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