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Last Updated: 2 years ago

Possible Interaction: Nitric Oxide and Sphingosine 1-Phosphate

Research Papers that Mention the Interaction

S1P significantly reduced NO formation and iNOS mRNA and protein expression, both in un-stimulated and IL-1beta stimulated bovine chondrocytes.
Osteoarthritis and cartilage  •  2008  |  View Paper
The prominent vasoactive actions of S1P in the maternal arteries of pregnant women are modulated by inhibitors of ROCKs and NO bioavailability.
Biology of reproduction  •  2007  |  View Paper
However, S1P also modulates endothelial cell exocytosis by activating endothelial nitric oxide synthase production of nitric oxide , which inhibits exocytosis.
Proceedings of the National Academy of Sciences of the United States of America  •  2004  |  View Paper
In addition, S1P treatment significantly suppressed NO generation accompanied by down-regulation of iNOS expression.
Inflammation  •  2011  |  View Paper
S1P inhibited NO production at concentrations higher than 0.1 μM; this was associated with the inhibition of iNOS protein and mRNA expression.
Thus, S1P inhibits IL-1β induction of NO production and iNOS expression in rat VSMCs through multiple mechanisms involving both PTX-sensitive and -insensitive G proteins coupled to S1P receptors.
Journal of Pharmacology and Experimental Therapeutics  •  2008  |  View Paper
Addition of S1P to cells induced an increase in intracellular calcium concentrations and NO production in cells.
Hepatology  •  2006  |  View Paper
S1P at higher than 0.1 microM inhibited the NO production induced by IL-1 beta in a concentration-dependent manner, in which S1P at 10 microM caused over 90% inhibition.
These results suggest that S1P modulates IL-1 beta induction of NO production by rat VSMCs through multiple mechanisms, partially via Edg-3 and Edg-5 receptor subtypes coupled to PTX-sensitive G proteins.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  2002  |  View Paper
SPP also stimulates eNOS phosphorylation and NO release and these effects are also attenuated by inhibition of Gi signaling, PI 3-kinase, and Akt.
The Journal of Biological Chemistry  •  2001  |  View Paper