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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“ S1P significantly reduced NO formation and iNOS mRNA and protein expression, both in un-stimulated and IL-1beta stimulated bovine chondrocytes.”
Spingosine-1-phosphate stimulates proliferation and counteracts interleukin-1 induced nitric oxide formation in articular chondrocytes.“The prominent vasoactive actions of S1P in the maternal arteries of pregnant women are modulated by inhibitors of ROCKs and NO bioavailability.”
“However, S1P also modulates endothelial cell exocytosis by activating endothelial nitric oxide synthase production of nitric oxide , which inhibits exocytosis.”
“In addition, S1P treatment significantly suppressed NO generation accompanied by down-regulation of iNOS expression.”
Sphingosine-1-Phosphate Attenuates Lung Injury Induced by Intestinal Ischemia/Reperfusion in Mice: Role of Inducible Nitric-Oxide Synthase“ S1P inhibited NO production at concentrations higher than 0.1 μM; this was associated with the inhibition of iNOS protein and mRNA expression.”
“Thus, S1P inhibits IL-1β induction of NO production and iNOS expression in rat VSMCs through multiple mechanisms involving both PTX-sensitive and -insensitive G proteins coupled to S1P receptors.”
“Addition of S1P to cells induced an increase in intracellular calcium concentrations and NO production in cells.”
“ S1P at higher than 0.1 microM inhibited the NO production induced by IL-1 beta in a concentration-dependent manner, in which S1P at 10 microM caused over 90% inhibition.”
“These results suggest that S1P modulates IL-1 beta induction of NO production by rat VSMCs through multiple mechanisms, partially via Edg-3 and Edg-5 receptor subtypes coupled to PTX-sensitive G proteins.”
“ SPP also stimulates eNOS phosphorylation and NO release and these effects are also attenuated by inhibition of Gi signaling, PI 3-kinase, and Akt.”
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