supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Silymarin
Research Papers that Mention the Interaction
“ SIL treatment significantly reduced the levels of LDH, nitric oxide , reactive oxygen species and the oxidants/antioxidants balance in Neuro-2A cells as compared to Mn-exposed cells.”
Manganese Induces Oxidative Stress, Redox State Unbalance and Disrupts Membrane Bound ATPases on Murine Neuroblastoma Cells In Vitro: Protective Role of Silymarin“ Silymarin dose-dependently inhibited both cytokine-induced NO production and cell death in RINm5F cells.”
“ Silymarin prevented IL-1beta+IFN-gamma-induced NO production and beta-cell dysfunction in human islets.”
“ Silymarin may inhibit the formation of free radicals and nitric oxide.”
“Moreover, silymarin administration promoted SIRT1, suppressed SREBP-1c mRNA expression, reduced liver nitric oxide and protein carbonyl content, and increased liver glycogen, catalase and glutathione peroxidase activity.”
Silymarin prevents lipid accumulation in the liver of rats with type 2 diabetes via sirtuin1 and SREBP-1c“Pretreatment with METg and silymarin attenuated significantly (p<0.01) marker enzymes, TP, MDA and NO formation as well as IL-6 and TNF-α production in liver homogenates.”
“Conclusion: The antidepressant-like effect of SM is probably mediated at least in part through NO and SM may increase NO tune.”
“Further study demonstrated that the gastroprotective effect of silymarin was blocked by nitric oxide (NO) synthase inhibitor l-NAME, SH blocker N-ethylmaleimide or TRPV1 antagonist capsazepine in ethanol-induced gastritis model.”
“These findings suggest that SMN at higher dosage level might exert pro-oxidant effect as an increase in the level of MDA and proinflammatory mediators such as NO , and upregulation of IL-1β in the hippocampus were shown.”
“Furthermore, an in vitro study on microglial BV2 cells showed that silymarin could inhibit nitric oxide and superoxide anion production, possibly by interfering with NF-κB nuclear translocation/activation.”
“Moreover, both Sm and silymarin treatment inhibited the elevation of hepatic inducible nitric oxide (iNOS) protein content and nitrite concentration in liver homogenate 24 h after CCl(4) intoxication.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback