Possible Interaction: Nitric Oxide and Serum Albumin, Human

“These data suggest that Na2Sn-treated HSA inhibits tyrosinase activity for melanin synthesis via two pathways; by directly inhibiting ROS signaling and by scavenging NO.”

“Although the in vivo half-life of NO is extremely short, HSA could prolong the half-life of NO via S-nitrosation at the position of Cys-34.”

“Continuous supplementation of NO by S-NO-HSA after LPS challenge prevents induction of NOS-2, provides significant protection of endotoxin-induced acute lung injury, and prevents early mortality in endotoxic shock in rats.”

“LPS-induced tissue increases in both NO and O2(-) production was decreased by HSA.”

“Second, compounds such as PNA can prolong the half-life of free (unbound, low molecular weight) nitroxides such as 4-hydroxy-2,2,6, 6-tetramethylpiperidine-N-oxyl (Tempol) in vivo.”

“Basal release of nitric oxide was reduced significantly in LAD rings exposed to zymosan-activated HS compared with HS alone.”

“Synchronous fluorescence and FT-IR results suggested that interactions between both nitrosyl ruthenium complexes and HSA affect the conformation of the protein.”

“It was calculated that in plasma the autoxidation of •NO is accelerated 1.38 times by HSA relative to water alone, but this becomes of little relevance when whole blood is simulated because of the rapid rate of •NO consumption by red blood cells.”

“ AGE-HSA and AGE-BSA decreased the NO levels in the supernatant in a dose and time-dependant manner.”

“Supplementation of NO by the novel NO donor S-nitroso human serum albumin ( S-NO-HSA ) may inhibit uncoupling of eNOS (feedback inhibition).”