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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Serine
Research Papers that Mention the Interaction
“ NO induces phosphorylation of p53 on serine 15 , which does not require ATM but rather appears to depend on the ATM-related ATR kinase.”
Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation“ Nitric oxide also elevates p53 expression, causing a concomitant increase in p53 serine 18 phosphorylation and p53 translocation from the cytoplasm to the nucleus.”
Nitric oxide‐induced cell death of cerebrocortical murine astrocytes is mediated through p53‐ and Bax‐dependent pathways“In the present study, L‐Ser was shown to enhance production of nitric oxide (NO), interleukin‐6 (IL‐6) and tumor necrosis factor α (TNF α) by lipopolysaccharide (LPS)‐stimulated cultured rat microglial cells.”
“Replacement of the acidic (aspartate 355) or basic (arginine 357 and arginine 363) amino acids located in the vicinity of cysteine 121 by serine leads to a marked reduction in the ability of nitric oxide to S-nitrosylate and inactivate hepatic methionine adenosyltransferase.”
“Individual amino acid concentrations were negatively affected with increasing NO (i.e. asparagine and glutamine with low N availability, serine and proline with high N availability).”
Rhizospheric NO affects N uptake and metabolism in Scots pine (Pinus sylvestris L.) seedlings depending on soil N availability and N source.“These findings demonstrated that L-serine has antioxidant and cytoprotective effects through the elevation of some crucial antioxidant factors such as Nrf2, HO-1 and NO.”
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