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Last Updated: 2 months ago

Possible Interaction: Nitric Oxide and Selenium



Research Papers that Mention the Interaction

NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia.
Biological Research  •  2016  |  View Paper
A low dose of 5 ng/mL selenium induced a significant decrease in macrophage NO production, but significant increase in hydrogen peroxide (H2O2) levels (respectively, p = 0.009, p < 0.001).
NO production and H2O2 levels were … increased with increasing concentrations of selenium ; the optimal macrophage activity levels were reached at 20 ng/mL. The concentration of 5 ng/mL of selenium induced a significant decrease in the bacterial arginase activity but a significant increase in the macrophage arginase activity.
PloS one  •  2015  |  View Paper
Se supplementation during dietary Cd obviously reduced Cd accumulation, NO production, mRNA level and activity of iNOS, oxidative stress, and histopathological damage in the cerebrum and cerebellum of chickens.
Biological Trace Element Research  •  2014  |  View Paper
Concurrent treatment with Se reduced the Cd-induced liver histopathological changes, oxidative stress, overexpression of NO and apoptosis, suggesting that the toxic effects of Cd on the liver is partly ameliorated by inorganic Se.
Ecotoxicology and environmental safety  •  2013  |  View Paper
Dietary Se significantly decreased renal lipid oxidation, phospho-P65, TNFα gene expression, MCP-1 and Cl-Tyr/Tyr, improved NO bioavailability in aorta but not in the renal microvasculature, and inhibited proteinuria.
Antioxidants & redox signaling  •  2013  |  View Paper
Selenium pretreatment significantly lowered tissue MDA and NO levels and increased tissue SOD and GPx activities in the Se groups, compared with those in the I/R groups (P < .05).
Journal of pediatric surgery  •  2012  |  View Paper
Although selenium (Se) was reported to inhibit nitric oxide (NO) production, it is unclear which signaling pathway is inhibited by Se.
Here, we investigated how Se inhibits NO production in LPS-stimulated RAW 264.7 cells.
These results suggest that Se down-regulates iNOS gene expression and NO production in the LPS-stimulated macrophages through inhibition of the NF-kappaB activation pathway but not the IFN-beta/STAT1 signaling pathway.
International immunopharmacology  •  2007  |  View Paper
We demonstrate that Se attenuated LPS-induced ROS and NO production in murine macrophage cultures in vitro.
Experimental biology and medicine  •  2004  |  View Paper
We conclude that diet supplementary selenium to inhibit NO generation can be a useful treatment in chronic inflammatory diseases.
Nutritional neuroscience  •  2003  |  View Paper
The contribution of NO to basal conductance was greater in control than in cholesterol-fed rabbits [2.2 +/- 0.4 vs. 1.1 +/- 0.3 ( SE ) ml.
American journal of physiology. Heart and circulatory physiology  •  2000  |  View Paper
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