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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nitric Oxide
supplement:
Saponin
Research Papers that Mention the Interaction
“ Saponin , essential oil and flavonoids could dose-dependently inhibit NO production in LPS-induced RAW 264.7 macrophages, whose inhibition rates were 65.4%, 73.0% and 80.4% at concentration of 50 μg/ml, respectively.”
Comparative antitumor and anti-inflammatory effects of flavonoids, saponins, polysaccharides, essential oil, coumarin and alkaloids from Cirsium japonicum DC.“ SF clearly suppressed the release of nitric oxide (NO) and tumor necrosis factor (TNF)-α, but not prostaglandin E2 (PGE2).”
“ Nitric oxide concentrations were increased by the treatment of crude saponin in conscious rats as well as in the cultured ECV 304 cells.”
“Akebia saponin D significantly decreased NO production and iNOS expression.”
Anti‐nociceptive and anti‐inflammatory potentials of Akebia saponin D“The production of nitric oxide and cytokines, induced by adipocyte-conditioned medium (3T3-CM), was significantly decreased by SF.”
“From this extract, eight compounds [two naphthofuranoxepins (1, 2), one phenanthraquinone (3), three steroids (4-6) and two steroidal saponins (7, 8)] were isolated and further investigated for their inhibitory properties of NO production.”
“6 L‐NAME and saponin also inhibited 5‐HT, ACh and substance P‐induced NO release (P < 0.05), without affecting equivalent responses to SNP.”
“ Saponin (three cycles of 2 min of 30 μg … 2 min control perfusion) reduced basal coronary NO content by a similar amount (307 ± 22 pmol min−1 g−1) but reduced basal coronary … ± 0.2 ml min−1 g−1 (P < 0.05 versus the effect of L‐NAME).”
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