Possible Interaction: Nitric Oxide and Rutin

“In addition, rutin down regulates the inducible nitric oxide synthase expression and up‐regulate the nuclear factor (erythroid‐related factor 2) expression.”

“The results showed that rutin may improve endothelial function by augmenting NO production in human endothelial cells.”

“…,rutin decreases …), NO , glutathione disulfide (GSSG), and malondialdehyde (MDA), reduces inducible nitric oxide synthase (iNOS) activity, attenuates mitochondrial damage, increases the glutathione (GSH)/GSSG ratio, enhances …), catalase (CAT) and glutathione peroxidase (GPx), and modulates the production of proinflammatory cytokines by decreasing TNF-α and IL-1β generation in microglia.”

“ Rutin also inhibited the reduction of total glutathione by nitric oxide.”

“ Rutin significantly decreased lung malondialdehyde content, increased lung glutathione content, superoxide dismutase activity, serum total antioxidant capacity, and decreased lung nitric oxide content.”

“Phenolic compounds in the range of 0.1–100 µM showed a dose-dependent inhibition of NO production, with quercetin, rutin , and kaempferol as the most potent ones.”

“ Rutin also induced a decrease in the mRNA levels of TNF, IL1β, IL6 and iNOS, reduced the production of IL6, TNF, and nitric oxide , and increased production of the M2 regulatory cytokine IL10 and arginase.”

“The 4 fractions and rutin effectively inhibited the production of reactive oxygen species, nitric oxide (NO), and interleukin-6.”

“ Rutin treatment blocked PrP(106–126)-mediated increases in reactive oxygen species production and nitric oxide release and helped slowing the decrease of neurotrophic factors that results from PrP accumulation.”

“ NO and PGE2 production as well as the iNOS and COX-2 expression were reduced by apocynin and rutin.”