Possible Interaction: Nitric Oxide and Riboflavin

“A possible role of riboflavin in the modulation of toxic and signal pathways of nitrogen oxide is discussed.”

“Recently, we have reported that NO production was inhibited by naturally-occurring proteasome inhibitors (quercetin, δ-tocotrienol, and riboflavin ) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and thioglycolate-elicited peritoneal macrophages from C57BL/6 mice.”

“ConclusionsResults of the current study demonstrate that δ-tocotrienol, riboflavin , and quercetin inhibit NO production by LPS-stimulated macrophages of all four strains of mice, and TNF-α secretion only by LPS-stimulated macrophages of C57BL/6 and BALB/c mice.”

“ Vitamin B2 … NO levels in accordance with a reduction in expression of inducible NO synthase (iNOS) both at 21 and 24 h. Accordingly, the reduction in … based on the inhibitory effect on local cytokine mRNA expression and iNOS would be responsible for the anti-septic effect of vitamin B2.”

“ Riboflavin treatment also decreased NO and TNF-α level possibly by inhibiting the NF-κβ pathway.”

“Nutrients such as arginine, antioxidants (vitamins C and E, lipoic acid, glutathione), and enzyme cofactors vitamins B2 and B3, folate, and tetrahydrobiopterin) help to elevate nitric oxide levels and may play an important role in the management of cardiovascular disease.”